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A REVIEW OF LEYDIG CELL HYPERPLASIA IN FISH MODELS: IMPLICATIONS FOR ENDOCRINE TOXICITY STUDIES
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J
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J
DOI：10.1016/j.yrtph.2026.106117.png)
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Abstract
En 中文
• Fish are suitable models for investigating chemically-induced Leydig cell hyperplasia (LCH) • Chemically-induced LCH in mammals involves a variety of direct and indirect mechanisms • Few examples exist of chemically-induced LCH in fish, and some are of questionable credibility • Diagnosis of chemically-induced LCH in fish can involve species-specific factors • Current evidence does not suggest that LCH itself should be considered adverse in fish
Keywords:
Leydig cell hyperplasia
fish models
endocrine toxicity
chemically-induced hyperplasia
species-specific factors
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