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A Robust Method for Perfusable Microvascular Network Formation In Vitro

delete2022-04-03
delete40
delete
OA
AI
Z
Zhengpeng Wan
A
Amy X. Zhong
张
张舜 (Shun Zhang)
P
Pavlou, Georgios
C
Coughlin, Mark F.
S
Sarah E. Shelton
H
Huu Tuan Nguyen
L
Lorch, Jochen H.
B
Barbie, David A.
K
Kamm, Roger D. *
DOI：10.1002/smtd.202200143delete
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Abstract

Abstract

En 中文
Micropost-based microfluidic devices are widely used for microvascular network (MVN) formation in diverse research fields. However, consistently generating perfusable MVNs of physiological morphology and dimension has proven to be challenging. Here, how initial seeding parameters determine key characteristics of MVN formation is investigated and a robust two-step seeding strategy to generate perfusable physiological MVNs in microfluidic devices is established.
Keywords:
cancer
microfluidics
microvasculatures
perfusable
physiological geometry

Journal

Small Methods cover
Small Methods
IF:
9.1
Papers:
4.3K
Citations:
2.2W

Organization

H
Harvard University
Scholars:
26.5W
Papers: 22.0W
Citations: 28.7W