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A self-amplifying nerve-fibroblast circuit drives colorectal cancer progression

delete2026-07-24
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PRE
AI
H
Hiroki Kobayashi
T
Tadashi Iida
Y
Yosuke Ochiai
A
Akihiro Sakai
R
Ruth A. White
Y
Yi Zeng
X
Xiaofei Zhi
J
Jin Qian
F
Feijing Wu
B
Biyun Zheng
J
Junya Arai
M
Masahiro Hata
H
Hualong Zheng
P
Puran Zhang
S
Shuang Li
Q
Quin T. Waterbury
J
Jonathan S. LaBella
H
Harry Nagendra
L
Leah Zamechek
A
Atsushi Ogura
DOI：10.1016/j.ccell.2026.06.018delete
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Abstract

Abstract

En 中文
• Cholinergic signaling via CHRM3 enhances innervation by upregulating NTN1 from CAFs • ACh and NTN1 promote cancer cell growth via the CHRM3-YAP and UNC5B-AKT axes • Blocking NTN1 or CHRM3 prolongs mouse survival by disrupting nerve-CAF crosstalk • High NTN1 expression is associated with shorter survival in CRC patients

Journal

Cancer Cell cover
Cancer Cell
IF:
44.5
Papers:
413
Citations:
5.6W

Organization

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