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A sensitive cilnidipine sensor based on copper oxide nano-particles and reduced graphene oxide coated glassy carbon electrode
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DOI：10.1007/s13738-026-03395-0.png)
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Abstract
En 中文
In this work, a composite material consisting of copper oxide nanoparticles (CuONPs) and reduced graphene oxide (rGO) was fabricated by a two-step reduction method. The CuONPs-rGO composite material was characterized by fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and electrochemical impedance spectroscopy (EIS). The electrochemical behavior of cilnidipine (CLP) at CuONPs-rGO coated glassy carbon electrode (CuONPs-rGO /GCE) was discussed. The results demonstrated that CuONPs-rGO composite film enhanced the electrochemical activity of the electrode. Additionally, the electrode performance of CuONPs-rGO/GCE was investigated in detail, which exhibited high selectivity and preferable stability since the deviation was less than +/- 5%. Within the range from 8.0 & times; 10(-)(8) to 3.0 & times; 10(-)(5) M, the variation of the peak current increased linearly with CLP concentration. CuONPs-rGO/GCE as a newly electrochemical sensor, it can be employed to detect the content of CLP in pharmaceutical samples. The recovery for CLP detection ranges from 98.44% to 103.57%, indicating that the fabricated CuONPs-rGO/GCE sensor is suitable for the application in pharmaceutical analysis.
Keywords:
Copper oxide nanoparticles
Graphene
Polydiallyldimethyl- ammonium chloride
Cilnidipine
Electrochemical sensor
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