A Sequentially Dual-enzyme Activatable Fluorescent Probe for Guiding Precise Surgical Resection and Postoperative Tumor Observation of Orthotopic Breast Tumor

2026-08-11

PRE

null Bin Zhao

Ying Yang

Tingting Yang

Ying Liu

Zijuan Hai

Shusheng Zhang

Miaomiao Zhang *

DOI：10.1016/j.snb.2026.140681

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• A new Cathepsin B andγ-glutamyl transpeptidase responsive fluorescent probe with high sensitivity, good selectivity, and high tumor to normal ratio. • A sequentially dual-enzyme activatable fluorescent probe for guiding precise surgical resection and postoperative tumor observation of orthotopic breast tumor. • A smart strategy for guiding precise surgical resection with delayed postoperative tumor regrowth.

A Sequentially Dual-enzyme Activatable Fluorescent Probe for Guiding Precise Surgical Resection and Postoperative Tumor Observation of Orthotopic Breast Tumor

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