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A single-centre analysis of nodal peripheral T-cell lymphomas in Southern Vietnam: Insights from the WHO 2022 classification
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Abstract
En 中文
Introduction: Peripheral T-cell lymphomas are rare, aggressive malignancies with significant diagnostic challenges due to their heterogeneity. Materials and Methods: This retrospective study analysed 43 nodal Peripheral T-cell lymphomas cases diagnosed between 2019 and 2024 at the Blood Transfusion Hematology Hospital in Southern Vietnam and reclassified them using the World Health Organization emerged as the most prevalent subtype (51.2%), markedly exceeding rates reported in Western (32.5%) and East Asian studies (36.2%). Despite the higher prevalence of Epstein-Barr Virus in Vietnam, the proportion of Epstein-Barr Virus positive in Peripheral T-cell lymphomas was not elevated (20%), suggesting additional genetic or environmental factors influencing lymphoma pathogenesis. Conclusion: These findings underscore the critical role of updated diagnostic standards and the utility of advanced markers in improving Peripheral T-cell lymphomas classification. This study provides rare insights into Peripheral T-cell lymphomas pathology in Vietnam, contributing valuable data to the global understanding of these rare lymphomas.
Keywords:
Peripheral T-cell lymphoma
Nodal TFH lymphoma
Epstein-Barr virus
WHO 2022 classification
Immunohistochemistry
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