A soil-inspired dynamically responsive chemical system for microbial modulation

doi:10.1038/s41557-022-01064-2

A soil-inspired dynamically responsive chemical system for microbial modulation

2022-10-24

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DOI：10.1038/s41557-022-01064-2

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Interactions between the microbiota and their colonized environments mediate critical pathways from biogeochemical cycles to homeostasis in human health. Here we report a soil-inspired chemical system that consists of nanostructured minerals, starch granules and liquid metals. Fabricated via a bottom-up synthesis, the soil-inspired chemical system can enable chemical redistribution and modulation of microbial communities. We characterize the composite, confirming its structural similarity to the soil, with three-dimensional X-ray fluorescence and ptychographic tomography and electron microscopy imaging. We also demonstrate that post-synthetic modifications formed by laser irradiation led to chemical heterogeneities from the atomic to the macroscopic level. The soil-inspired material possesses chemical, optical and mechanical responsiveness to yield write-erase functions in electrical performance. The composite can also enhance microbial culture/biofilm growth and biofuel production in vitro. Finally, we show that the soil-inspired system enriches gut bacteria diversity, rectifies tetracycline-induced gut microbiome dysbiosis and ameliorates dextran sulfate sodium-induced rodent colitis symptoms within in vivo rodent models.

Keywords:

NANOWIRE-BACTERIA HYBRIDS

RAMAN-SPECTROSCOPY

ELASTIC-MODULUS

WATER

VISUALIZATION

INDENTATION

ELASTOMER

HARDNESS

IR

A soil-inspired dynamically responsive chemical system for microbial modulation

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