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A Stromal–Immune computational pathology Signature for prognosis and immune checkpoint inhibitor Response in localized, locally advanced and metastatic urothelial carcinoma: A Multicenter retrospective Study
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DOI：10.1016/j.ejca.2026.116979.png)
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Abstract
En 中文
• Automated H&E analysis integrates TLS density and tumor–stroma ratio. • In 884 patients from five cohorts, the TLS–TSR score independently predicted PFS. • The signature reflected immune–stromal biology and immunotherapy response.
Keywords:
Urothelial carcinoma
Tertiary lymphoid structures
Tumor–stroma ratio
Digital pathology
Prognostic biomarker
ICI response
Journal
IF:
7.1
Papers:
2.6W
Citations:
3.8W
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