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A survey of transfusion support strategies for passenger lymphocyte syndrome in minor ABO-mismatched allogeneic hematopoietic stem cell transplantation
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DOI：10.1111/trf.70282.png)
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Abstract
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Passenger lymphocyte syndrome (PLS) is a hematologic complication of ABO blood-type minor incompatibility that can occur following both solid-organ and hematopoietic stem cell transplant (HSCT). HSCT patients usually require red blood cell (RBC) transfusions until they achieve full erythroid engraftment. It is unclear whether the blood bank should honor the recipient's blood type or the donor's blood type at the time of issuing RBC products for minor ABO-incompatible HSCT patients prior to full engraftment. To avoid this confusion, blood group O RBCs are often transfused. However, the role of this approach in the prevention of PLS in minor ABO-mismatched HSCT recipients prior to full engraftment is not well understood.
Keywords:
hematopoietic stem cell
hemolysis
minor ABO mismatch
passenger lymphocyte syndrome
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