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A Synthetic Method for Spirocyclobutanes via Ring Expansion of Donor–Acceptor Spirocyclopropanes with Stabilized Sulfonium Ylides
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DOI：10.1021/acs.joc.6c00210.png)
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Abstract
En 中文
A sulfonium ylide-mediated ring expansion of donor–acceptor spirocyclopropanes has been developed to provide access to spirocyclobutanes. Spirocyclopropanes derived from 1,3-indandione undergo efficient ring expansion with stabilized sulfonium ylides, affording the corresponding spirocyclobutanes as single isomers in high yield. Given that spirocyclic frameworks, with their rigid three-dimensional architecture, play a key role in drug discovery, spirocyclobutanes represent particularly promising core structures. This synthetic method is expected to make a significant contribution to pharmaceutical development.
Keywords:
spirocyclobutanes
ring expansion
sulfonium ylide
donor–acceptor spirocyclopropanes
synthetic method
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3.6
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Citations:
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