A TFPI-1 homolog from Sebastes schlegelii: Characterization of C-terminal endogenous cleavage and antimicrobial role of derived peptide

Zhi-shu Zhu

doi:10.1016/j.fsi.2026.111649

A TFPI-1 homolog from Sebastes schlegelii: Characterization of C-terminal endogenous cleavage and antimicrobial role of derived peptide

2026-08-12

0

PRE

AI

Z

Zhi-shu Zhu

Z

Zi-Yue Chen

G

Guang-Hua Wang

H

Hao Jing

K

Kai Yang

N

Nuo Sun

Y

Yi-lin Du

Z

Zi-Qi Wang

M

Min Zhang *

DOI：10.1016/j.fsi.2026.111649

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Abstract

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• A novel TFPI-1 homolog SsTFPI-1 was identified, with expression induced by pathogens and poly(I:C). • SsTFPI-1 undergoes endogenous C-terminal cleavage in EPC cells. • TS20 is active against Micrococcus luteus, and can penetrate cell membranes and bind nucleic acids. • Both in vitro and in vivo assays demonstrate that TS20 effectively inhibits infection by SVCV and RBIV-C1.

Keywords:

Sebastes schlegelii

TFPI-1

TS20

Endogenous cleavage

Antimicrobial activity

A TFPI-1 homolog from Sebastes schlegelii: Characterization of C-terminal endogenous cleavage and antimicrobial role of derived peptide

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