A zinc deficiency leads to non-inflammatory pruritus by modifying opioid receptor signaling

Hozumi Sano

doi:10.1016/j.jdermsci.2026.05.006

A zinc deficiency leads to non-inflammatory pruritus by modifying opioid receptor signaling

2026-05-28

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PRE

AI

H

Hozumi Sano

R

Reiko Kamijima

M

Mikiro Takaishi

S

Shigetoshi Sano *

DOI：10.1016/j.jdermsci.2026.05.006

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• Patients with non-inflammatory pruritus (NIP) showed zinc deficiency (ZD), which was more pronounced than those with inflammatory pruritus (IP). • Zinc supplementation improved NIP symptom along with normalization of zinc levels. • Compared to control mice, ZD model mice showed an increased sensitivity to morphine-mediated pruritus, which were reversed by kappa opioid receptor agonist, nalfurafine, pretreatment. • The results implicated that zinc is critically related to pruritus through modulation of opioid receptor signaling.

Keywords:

zinc deficiency

non-inflammatory pruritus

opioid receptor signaling

nalfurafine

morphine-mediated pruritus

A zinc deficiency leads to non-inflammatory pruritus by modifying opioid receptor signaling

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