Aberrant effective connectivity in gray matter volume-altered brain regions in males with tobacco use disorder: A multimodal study combining meta-analysis and spectral DCM

2026-04-28

PRE

Guohao Lu

Yichen Guo

Longyao Ma

Xinyu Wang

Hui Zhang

Mengzhe Zhang

Weijian Wang

Shaoqiang Han

Yong Zhang *

DOI：10.1016/j.pnpbp.2026.111726

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• Integrating VBM meta-analysis and spectral DCM characterizes neurodynamics in males with tobacco use disorder. • Results reveal a system-level imbalance between cortical regulation and striatal excitability. • Intrinsic self-connection of the putamen robustly predicts nicotine dependence severity.

Keywords:

VBM meta-analysis

spectral DCM

tobacco use disorder

cortical regulation

striatal excitability

Aberrant effective connectivity in gray matter volume-altered brain regions in males with tobacco use disorder: A multimodal study combining meta-analysis and spectral DCM

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