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Aberrant White Matter Microstructure in Youth with a High Risk for Bipolar Disorder
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DOI：10.1016/j.bpsc.2025.08.017.png)
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Abstract
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Advances in neuroimaging of bipolar disorder (BD) have highlighted key structural and functional abnormalities in prefrontal-limbic circuits. Youth with a family history of BD often experience early onset of mood symptoms that may increase their risk for developing BD. However, etiological mechanisms underlying this risk remain poorly understood. We aimed to identify white matter connectivity abnormalities by comparing regional microstructure in high-risk youth and healthy controls (HC).
Keywords:
Bipolar disorder
DTI
Youth
Automated fiber quantification
high-risk
tractography
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