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Abnormal extracellular matrix deposition by fascial fibroblasts underlies the connective tissue pathology in the disease Radial Dysplasia
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DOI：10.1016/j.matbio.2026.02.004.png)
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Abstract
En 中文
• Fascial fibroblast matrisome changes are present in a human limb birth defect. • Matrix composition changes cause disruption of material properties of fascia in human disease. • Fascial fibroblasts are a heterogeneous cell population, altered in human disease. • IL6 restores normal matrix composition and cell behaviour of disease fascial fibroblasts
Keywords:
fascial fibroblasts
extracellular matrix
radial dysplasia
matrix composition
IL6
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