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Activating Sigma1R by fluoxetine suppresses neuronal ferroptosis in epilepsy by inhibiting MDM2-mediated GPX4 ubiquitination
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DOI：10.1016/j.jare.2026.07.060.png)
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Abstract
En 中文
• FLX inhibits neuronal ferroptosis and protects mice from epilepsy via Sigma1R. • The FLX/Sigma1R axis stabilizes GPX4, a ferroptosis regulator, to inhibit ferroptosis. • The FLX/Sigma1R blocks MDM2-driven GPX4 ubiquitination at Lys162 and Lys167. • The FLX/Sigma1R inhibits MDM2 expression through JNK/p38 MAPK signaling.
Keywords:
Epilepsy
Ferroptosis
Fluoxetine
Sigma1R
GPX4
Ubiquitination
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