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Active Hydrogenation Catalyst with a Structured, Peptide-Based Outer-Coordination Sphere
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DOI：10.1021/cs3004177.png)
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Abstract
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The synthesis, catalytic activity, and structural features of a rhodium-based hydrogenation catalyst containing a phosphine ligand coupled to a 14-residue peptide are reported. Both CD and NMR spectroscopy show that the peptide adopts a helical structure in 1:1:1 TFE/MeCN/H2O that is maintained when the peptide is attached to the ligand and when the ligand is attached to the metal complex. The metal complex hydrogenates aqueous solutions of 3-butenol to 1-butanol at 360 +/- 50 turnovers/Rh/h at 294 K. This peptide-based catalyst represents a starting point for developing and characterizing a peptide-based outer-coordination sphere that can be used to introduce enzyme-like features into molecular catalysts.
Keywords:
outer-coordination sphere
peptide catalyst
bioinspired catalyst
hydrogenation catalysis
artificial enzyme
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