Active learning-based autonomous control for fed-batch fermentation process under parameter fluctuations

Liufu Li

doi:10.1016/j.compchemeng.2026.109910

Active learning-based autonomous control for fed-batch fermentation process under parameter fluctuations

2026-10-02

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Rodrigo Ledesma-Amaro

DOI：10.1016/j.compchemeng.2026.109910

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Abstract

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• A novel Goal-Oriented Autonomous Control (GOAC) framework is proposed. • GOAC actively balances process exploitation and active exploration. • A dynamic interval allocation algorithm optimizes the exploration space. • The strategy maximizes product yield in the fed-batch fermentation.

Keywords:

Fed-batch fermentation

Autonomous control

Dynamic interval allocation

Active learning

Active learning-based autonomous control for fed-batch fermentation process under parameter fluctuations

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