arrow
Return

Adaptive Framework for Data-Driven Probabilistic Design Space Identification

delete2026-05-16
delete0
PRE
AI
R
Ranjith Chiplunkar *
A
Andrea Galeazzi
M
Maria M. Papathanasiou
C
Cleo Kontoravdi *
DOI:10.1016/j.ces.2026.124255delete
deleteOriginal
deleteOriginal request for help
deleteShare
deleteSave
Abstract

Abstract

En 中文
• Design space identification for systems without reliable mechanistic models • Feasibility-informed sampling guides efficient exploration of feasible regions • Modified Delaunay triangulation method enables adaptive, geometry-driven sampling • Deterministic strategy yields consistent and reproducible design space estimates • Reduces experimentation and avoids variability seen in batch Bayesian optimization
Keywords:
Quality by Design
Design Space Identification
Adaptive Sampling
Design of Experiments
AI Summary

AI Summary

Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Chemical Engineering Science cover
Chemical Engineering Science
IF:
4.3
Papers:
2.3W
Citations:
5.5W

Organization

I
imperial college london
Scholars:
9.9K
Papers: 4.4K
Citations: 0
Cited Papers

Cited Papers

Design of experiments and design space approaches in the pharmaceutical bioprocess optimization
err2021-09-01
err0
PREAI
errAlice Kasemiire; Hermane T. Avohou; Charlotte De Bleye; Pierre-Yves Sacre; Elodie Dumont; Philippe Hubert; Eric Ziemons
errShare
errSave
Definition of Design Spaces Using Mechanistic Models and Geometric Projections of Probability Maps
err2015-08-04
err50
PREAI
errGarcia-Munoz, Salvador; Luciani, Carla V.; Vaidyaraman, Shankar; Seibert, Kevin D.
errShare
errSave
Taking the Human Out of the Loop: A Review of Bayesian Optimization
err2016-01-01
err3.5K
PREAI
errShahriari, Bobak; Swersky, Kevin; Wang, Ziyu; Adams, Ryan P.; de Freitas, Nando
errShare
errSave
Bayesian Approach to Probabilistic Design Space Characterization: A Nested Sampling Strategy
err2019-11-26
err24
errOAAI
errKusumo, Kennedy P.; Gomoescu, Lucian; Paulen, Radoslav; Munoz, Salvador Garcia; Pantelides, Constantinos C.; Shah, Nilay; Chachuat, Benoit
errShare
errSave
An Optimization-Based Framework to Define the Probabilistic Design Space of Pharmaceutical Processes with Model Uncertainty
err2019-02-14
err0
errOAAI
errDaniel Laky; Shu Xu; Jose S. Rodriguez; Shankar Vaidyaraman; Salvador García Muñoz; Carl Laird
errShare
errSave
researcher View more