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Adenosine as a metabolic checkpoint in CD8+ T cell dysfunction
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DOI：10.1016/j.it.2026.06.005.png)
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Abstract
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Adenosine functions as a context-integrating metabolic checkpoint that constrains CD8+ T cell activity. Distinct drivers in cancer and chronic infection induce a shared state of dysfunction in CD8+ T cells. Adenosine signaling reinforces checkpoint pathways and stabilizes dysfunctional T cell states. Therapeutic targeting of the adenosine axis requires combination and context-specific strategies.
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