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Adhesion molecules-targeted membrane vesicle coatings restore vascular integrity in cardiovascular implants
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DOI：10.1016/j.mtadv.2026.100901.png)
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Abstract
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• The Silicon substrate was coated with macrophage-derived membrane vesicles carrying ligands for inflamed endothelial receptors. • The surface coating promotes ligand-mediated interactions, facilitating endothelial cell adhesion and growth. • The coated surface supports the symbiotic growth of endothelial and smooth muscle cells (SMCs), preventing SMCs from adopting a synthetic phenotype. • Our surface coating inhibits NF-kB activation, regulates VWF, and preserves VE-Cadherin-mediated cell junction stability.
Keywords:
Endothelialization
Macrophage-derived vesicle
Cardiovascular devices
Vascular integrity
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