.png){kind=icon}
.png){kind=icon}
Return
Adipocyte caspase-1 deficiency promotes white fat beiging via COX7A2L-dependent mitochondrial respiration
.png){kind=icon}
OA
AI
Y
J
W
F
Y
Y
H
T
R
S
L
R
X
肖
X
DOI：10.1016/j.metabol.2026.156729.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Breaks from the classic inflammation/pyroptosis paradigm to reveal a non-inflammatory, metabolic role of Caspase-1 in driving adipocyte beiging. • Defines the upstream cAMP-C/EBPβ axis that suppresses Caspase-1, outlining a complete cAMP-Caspase-1-COX7A2L regulatory pathway. • Proposes a novel mechanism where Caspase-1 cleaves COX7A2L to inhibit mitochondrial respiration, based on proteomics and validation. • Confirms that adipocyte Caspase-1 deficiency promotes beiging and protects against diet-induced obesity and metabolic dysfunction.
Keywords:
Adipocyte
Caspase-1
White fat beiging
COX7A2L
Metabolic homeostasis
Journal
M
IF:
11.9
Papers:
9.6K
Citations:
2.1W
Organization
Cited Papers