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Adipose TGFβ-asprosin memory promotes obesity relapse and offspring obesity susceptibility

delete2026-08-11
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OA
AI
B
Brian C. Kim
H
Hiba Obeid
Y
Yi Fan Chen
C
Christopher Kim
A
Adam Lieberman
B
B. BASU
E
Elizabeth S. Silva
M
Meng Jingzhi
K
Kyle A. Starost
N
Natalia Aladyshkina
I
Ila Mishra
S
Seth J. Field
A
Atul R. Chopra *
DOI:10.1016/j.celrep.2026.117809delete
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Abstract

Abstract

En 中文
• TGF-β1 induces a persistent adipose transcriptional memory • Sustained asprosin elevation promotes obesity relapse after weight loss • Maternal TGF-β1 increases offspring susceptibility to diet-induced obesity • Blocking the TGF-β1-asprosin-Ptprd axis prevents relapse and offspring obesity
Keywords:
obesity
weight regain
developmental programming
epigenetic memory
asprosin
FBN1
TGF-β1
CP: metabolism
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Cell Reports cover
Cell Reports
IF:
6.9
Papers:
1.7W
Citations:
10.2W

Organization

U
University Hospitals Cleveland Medical Center
Scholars:
265
Papers: 130
Citations: 1.3K
C
case western reserve university
Scholars:
2.6K
Papers: 1.3K
Citations: 0
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