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Advances in Nanocrystal Scintillators for X-Ray Imaging and Biomedical Applications
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DOI：10.31635/ccschem.025.202506233.png)
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Abstract
En 中文
Nanocrystal scintillators are redefining the landscape of radiation detection and biomedical imaging, offering a highly tunable, scalable, and multifunctional platform for next-generation diagnostics and therapy. Their bottom-up synthesis enables low-temperature, cost-effective fabrication of large-area detectors with high spatial resolution and structural flexibility. Through precise control over crystal phase, dimensionality, and surface chemistry, nanocrystal scintillators achieve customizable emission properties, fast response times, and seamless integration with flexible substrates and photonic devices. These features are particularly advantageous for advanced biomedical applications, including high-resolution in vivo imaging, radiotherapy of deep-seated lesions, biosensing, and optogenetic modulation. Here, we present a minireview that outlines the fundamental mechanisms of X-ray-induced luminescence, highlights recent advances in nanocrystal scintillator development-from halide perovskites and lanthanide-doped systems to lead-free analogs-and discusses the key material and engineering challenges that remain. Looking ahead, innovations in surface passivation, hybrid architectures, and biocompatibility will be critical for translating these materials from proof-of-concept demonstrations to real-world clinical and industrial applications.
Keywords:
nanocrystal scintillator
X-ray imaging
radioluminescence
biomedical applications
perovskites
Journal
IF:
9.2
Papers:
1.8K
Citations:
9.9K