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Aerocavin Is an Antibiotic with Potent and Specific Anti-Neisserial Activity
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DOI：10.1021/acsinfecdis.6c00197.png)
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Abstract
En 中文
Gonorrhea, caused by Neisseria gonorrhoeae, is a widespread sexually transmitted disease that is becoming resistant to all currently used antibiotics. Therefore, new therapeutics for gonorrhea are desperately needed. Here, we show that a natural product, aerocavin, is highly potent and specific against Neisseria. Aerocavin accumulates in N. gonorrhoeae at high levels and inhibits bacterial RNA polymerase (RNAP) by binding the switch region. Aerocavin resistance mutations evolve in N. gonorrhoeae at a low rate and are absent in clinical isolates. Previously overlooked narrow-spectrum antimicrobials like aerocavin may enable microbiome-sparing treatments of gonorrhea.
Keywords:
Antimicrobial agents
Bacteria
Genetics
Genomics
Peptides and proteins
narrow-spectrum antibiotics
gonorrhea
Neisseria
RNA polymerase
aerocavin
ripostatin
Journal
IF:
3.8
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2.4K
Citations:
6.9K
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Cited Papers