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Ag-containing high-entropy nitride coatings promote bone regeneration by mediating the MAPK/ERK signaling pathway

delete2026-04-30
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PRE
AI
L
Linhe Lv
C
Chuanyao Dong
J
Jun Ma
Z
Zheng Yang
M
Min Hu *
X
Xiaoxi Wei *
DOI：10.1016/j.colsurfb.2026.115770delete
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Abstract

Abstract

En 中文
• Stable 5.7 at% Ag HEN coating showed the best overall performance. • The coating strongly inhibited F. nucleatum and P. gingivalis. • S2 enhanced osteoblast differentiation and matrix mineralization in vitro. • S2 promoted bone regeneration and osseointegration in rabbit tibiae. • MAPK/ERK pathway activation mediated the pro-osteogenic effect of S2.
Keywords:
Ag-containing high-entropy nitride
bone regeneration
osteoblast differentiation
MAPK/ERK pathway
osseointegration

Journal

C
Colloids and Surfaces B: Biointerfaces
IF:
5.6
Papers:
1.4W
Citations:
4.2W

Organization

J
Jilin University
Scholars:
8.4W
Papers: 5.5W
Citations: 8.9K
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