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Age-associated B-cells predict coronary events in humans and aggravate murine atherosclerosis

delete2026-07-11
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OA
AI
J
Jill de Mol, PhD
P
Pernilla Katra, PhD
V
Virginia Smit, PhD
A
Anna Witteveen, MSc
L
Lukas Tomas, MD PhD
L
Linda Andersson, MSc
S
Scott W M Engels, MSc
S
Samuel Andersson, MSc
M
Mireia N A Bernabé Kleijn, BSc
A
Alexandru Schiopu, MD PhD
E
Eva Bengtsson, PhD
I
Ilze Bot, Prof. PhD
D
Daniel Engelbertsen, PhD
J
Johan Kuiper, Prof. PhD
H
Harry Björkbacka, PhD
A
Amanda C Foks, PhD *
DOI：10.1093/cvr/cvag154delete
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Abstract

Abstract

En 中文
Aging is a major risk factor for cardiovascular disease (CVD) and is also linked to a functional decline of the immune system. B-cells contribute to atherosclerosis progression by antibody secretion, antigen presentation and T-cell regulation. During aging, CD11c + CD21low B-cells accumulate, but it is unclear whether these age-associated B-cells (ABCs) are linked with incident cardiovascular events in humans and if they contribute to the progression of atherosclerosis.

Journal

Cardiovascular Research cover
Cardiovascular Research
IF:
13.3
Papers:
1.2W
Citations:
2.8W

Organization

L
lmu university hospital
Scholars:
267
Papers: 71
Citations: 0
L
leiden university
Scholars:
2.2K
Papers: 1.0K
Citations: 0
L
Lund University
Scholars:
2.0K
Papers: 861
Citations: 5.1W
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