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Age-associated increases in PAI-1 silenced with siRNA-lipid nanoparticles reduces thrombosis and prolongs lifespan

delete2026-01-29
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OA
AI
F
Francesca Ferraresso
C
Chad W Skaer
Z
Zimu Wei
W
Woosuk S. Hur
H
Hongyin Y
M
Monica Seadler
T
Taylor H. Y. Chen
W
Wen Dai
P
Paul, Manoj
C
Catherine LaPointe
L
Laura M. Ketelboeter
H
Hayley Lund
G
Geoffrey G. Rodriguez
L
Lih Jiin Juang
A
Amy W. Strilchuk
Y
Youjie Zhang
P
Pieter R. Cullis
M
Mitchell Dyer
A
Allison Gerras
Q
Qizhen Shi
DOI：10.1182/blood.2025029834delete
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Abstract

Abstract

En 中文
• siRNA targeting PAI-1 encapsulated in lipid nanoparticles lowers PAI-1 levels in age-associated disease models with no overt toxicity • A reduction in circulating PAI-1 levels reduced thrombosis in young and aged mice and prolonged lifespan in a fast-aging mouse model.
Keywords:
PAI-1
siRNA
lipid nanoparticles
thrombosis
lifespan

Journal

Blood cover
Blood
IF:
23.1
Papers:
5.4K
Citations:
16.6W

Organization

No organization information available