Age-related differences in motor learning, sensorimotor neurochemistry, and cortical reactivity co-occur but are dissociated

2026-06-25

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Marten Nuyts *

Sima Chalavi

Geraldine Rodriguez-Nieto

Raf Meesen

Stephan P. Swinnen

Sybren Van Hoornweder

DOI：10.1016/j.neurobiolaging.2026.06.008

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• The effect of age on motor learning, MRS GABA, and TMS-EEG response was quantified. • Age effects on motor learning capacity and sensorimotor neurophysiology co-occur. • Neurophysiology does not mediate age-related simple/complex motor learning decline. • Motor task complexity modulates neurophysiology - motor learning relationships. • GABA at rest predicts simple learning, task-related GABA predicts reactivity.

Age-related differences in motor learning, sensorimotor neurochemistry, and cortical reactivity co-occur but are dissociated

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