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Ageing-related tau astrogliopathy in a population-based study of the oldest old (Vantaa 85+)

delete2026-07-27
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OA
AI
B
Benjamin Englert *
S
Sara Savola
J
Jarno Tuimala
K
Kia Colangelo
E
Elizaveta Mikhailenko
H
Henri Puttonen
O
Olli Tynninen
L
Liisa Myllykangas
DOI:10.1016/j.nbd.2026.107538delete
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Abstract

Abstract

En 中文
• Ageing-related tau astrogliopathy (ARTAG) is frequent in the oldest old (79.6%). • ARTAG is associated with male sex (OR: 2.39 [1.11–5.13] for medial temporal lobe ARTAG). • Any ARTAG is associated with argyrophilic grains (p = 0.022, OR = 2.12 [1.11–4.03]). • LATE-NC and hippocampal sclerosis of ageing are associated with various ARTAG subtypes. • Micro- and small infarcts are associated with various ARTAG subtypes.
Keywords:
ARTAG
Neurodegeneration
Astrogliopathy
Tau pathology
Dementia
Ageing

Journal

Neurobiology of Disease cover
Neurobiology of Disease
IF:
5.6
Papers:
6.7K
Citations:
2.1W

Organization

U
University of Helsinki
Scholars:
4.2K
Papers: 1.7K
Citations: 5.1W
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