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AI-driven therapeutic antisense oligonucleotide for processing-deficient progeroid laminopathies
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DOI：10.1016/j.medj.2026.101193.png)
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Abstract
En 中文
• Deep-learning frameworks enable in silico screening of antisense oligonucleotides • Antisense oligonucleotides treat processing-deficient progeroid laminopathies • Therapeutic efficacy validated in cardiomyocytes, cardiac organoids, and mice • Long-term treatment improves lifespan and healthspan in progeroid mice
Keywords:
Progeroid laminopathy
Hutchinson-Gilford progeria syndrome
antisense oligonucleotide
LMNA
deep learning
senescence
induced pluripotent stem cells
cardiomyocytes
cardiac organoids
Pre-clinical research
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