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AIE-Pharmacology: Acacetin and NMN co-delivery rescues sperm motility
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DOI：10.1016/j.mtbio.2026.103387.png)
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Abstract
En 中文
• This study introduces the "AIE-Pharmacology" paradigm by identifying the natural flavonoid Acacetin as a novel intrinsic AIEgen with ESIPT characteristics, enabling self-monitored therapy for asthenozoospermia. • The engineered EVs@N+A nanoplatform successfully overcomes the blood-testis barrier (BTB) to co-deliver Acacetin and NMN, leveraging the inherent biocompatibility of extracellular vesicles for targeted testicular accumulation. • This dual-therapy strategy synergistically rescues sperm motility and spermatogenesis by simultaneously inhibiting ferroptosis via the Nrf2/GPX4 pathway and rejuvenating cellular metabolism through NAD+-dependent ATP restoration.
Keywords:
Aggregation-induced emission
AIE-Pharmacology
Aggregate science
Acacetin
Asthenozoospermia
Ferroptosis
Journal
IF:
10.2
Papers:
3.6K
Citations:
9.5K
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