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Alpha-cadinol in Hinoki cypress induces hyaluronic acid production in dermal cells possibly through ERK signaling
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DOI：10.1016/j.jff.2026.107394.png)
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Abstract
En 中文
• ・Hinoki cypress trunk essential oil promoted hyaluronic acid production in NB1RGB cells. • Alpha-cadinol strongly promoted hyaluronic acid production. • Alpha-cadinol did not dramatically alter HAS expression. • Alpha-cadinol promotes HA production, possibly through ERK phosphorylation.
Keywords:
Chamaecyparis obtusa
Hyaluronic acid
Α-Cadinol
ERK phosphorylation
HAS2
NB1RGB
Bio-HABP
biotinylated hyaluronic acid–binding protein
BSA
bovine serum albumin
DABCO
1,4-diazabicyclo (2.2.2) octane
DMSO
dimethyl sulfoxide
EOHC
essential oil from Hinoki cypress
ERK
extracellular signal–regulated kinase
EtOH
ethanol
FBS
fetal bovine serum
HA
hyaluronic acid
HABP
hyaluronic acid–binding protein
HAS
hyaluronic acid synthase
MEMα
minimum essential medium–α
MTT
3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide
PBS
phosphate-buffered saline
PBST
PBS with 0.05% Tween 20
PFA
paraformaldehyde
SD
standard deviation
TBS
Tris-buffered saline
TBST
TBS with 0.05% Tween 20
TGFβ1
transforming growth factor–1.
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