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Alpha-ketoglutarate ameliorates diabetes-associated skeletal muscle fibrosis by restoring TET2-dependent epigenetic remodeling in CD90 positive fibro-adipogenic progenitors

delete2026-08-10
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PRE
AI
Z
Zhou-jie Tong
Y
Yi-hui Li
M
Ming Song
Y
Ya-nan Sheng
Y
Yan-zhao Wu
Y
Yuan-yuan Shang
B
Bo-ang Hu
B
Bin Lu
P
Ping Zhu
G
Gan-qi Wang
H
Hao-jie Zhan
L
Lu Han
W
Wei Zhang
Z
Zhi-hao Wang *
M
Ming Zhong *
DOI：10.1016/j.metabol.2026.156731delete
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Abstract

Abstract

En 中文
• Elevated L-2HG and reduced α-KG drive CD90+ FAP dysfunction in diabetic skeletal muscle. • The α-KG/L-2HG imbalance inhibits TET2, causing CD90+ FAP chromatin hypermethylation. • TET2-dependent epigenetic remodeling triggers aberrant asymmetric division related polarity program in CD90+ FAPs. • Dietary α-KG restores CD90+ FAP symmetry and alleviates muscle fibrosis in T2DM mice. • Targeting the α-KG-TET2 axis offers a metabolic therapy for diabetic muscle fibrosis.

Journal

M
Metabolism-Clinical and Experimental
IF:
11.9
Papers:
9.6K
Citations:
2.1W

Organization

S
shandong university
Scholars:
9.1W
Papers: 6.3W
Citations: 94
S
shandong key laboratory of brain health and function remodeling
Scholars:
2
Papers: 1
Citations: 0
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