Alteration of Colonic Circadian Rhythm by Gut Microbiota Dysbiosis and SCFA Reduction Links Chronic Stress-Induced Depressive-Like Behavior

Xuli Wang

doi:10.1016/j.psyneuen.2026.107869

Alteration of Colonic Circadian Rhythm by Gut Microbiota Dysbiosis and SCFA Reduction Links Chronic Stress-Induced Depressive-Like Behavior

2026-04-29

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PRE

AI

X

Xuli Wang

R

Ruisi Liu

Y

Yudong Lin *

M

Mingmei Zhou *

DOI：10.1016/j.psyneuen.2026.107869

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• Multi-omics reveal a gut-to-brain pathway linking chronic stress to depressive-like behaviors. • Stress-induced gut dysbiosis and SCFA reduction correlate with colonic circadian clock alteration. • Altered colonic clock links to impaired intestinal barrier and elevated systemic inflammation. • Hippocampal neuroinflammation and synaptic gene changes coincide with this peripheral pathology.

Keywords:

gut microbiota dysbiosis

circadian rhythm

short-chain fatty acids

depressive-like behavior

neuroinflammation

Alteration of Colonic Circadian Rhythm by Gut Microbiota Dysbiosis and SCFA Reduction Links Chronic Stress-Induced Depressive-Like Behavior

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