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Alternate-Day Fasting Enhances Leptin Sensitivity via JMJD3-Dependent Epigenetic Regulation of the Leptin Receptor in the Hypothalamus
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DOI：10.1016/j.jnutbio.2026.110476.png)
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Abstract
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• Alternate-day fasting enhances leptin responsiveness in diet-induced obese mice. • Alternate-day fasting upregulates hypothalamic leptin receptor expression. • Alternate-day fasting reduces repressive H3K27 methylation at the LepRb promoter. • JMJD3 mediates fasting-induced epigenetic remodeling of LepRb.
Keywords:
Intermittent fasting
alternate-day fasting
leptin resistance
leptin receptor
JMJD3
epigenetic regulation
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