Ameliorative role of whey supplementation in age-associated testicular dysfunction: Morphometric, immunohistochemical, ultrastructural, and biochemical evidence with emphasis on aquaporin-1 and transition protein-2

2026-05-06

PRE

Nermeen I. Ashry

Heba A. El-Ghaweet

Yasmin Khalifa

Ghada Mutawa *

DOI：10.1016/j.tice.2026.103574

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• Whey reverses age-induced seminiferous tubular atrophy. • Restores germ cell height and reduces inactive tubules. • Preserves mitochondrial ultrastructure and 9 + 2 axoneme. • Suppresses caspase-3 activation and Annexin-V apoptosis. • Reduces oxidative stress and IL-6 in aged testes.

Keywords:

whey supplementation

testicular dysfunction

aging

oxidative stress

apoptosis

Ameliorative role of whey supplementation in age-associated testicular dysfunction: Morphometric, immunohistochemical, ultrastructural, and biochemical evidence with emphasis on aquaporin-1 and transition protein-2

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