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An acute temperature rise to 40°C inhibits free fatty acid uptake into white adipocytes
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DOI：10.1080/21623945.2026.2626121.png)
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Abstract
En 中文
Fever reflects a physiological rise in body temperature accompanied by elevated production of adrenaline. The increased body temperature in fever is caused by shivering thermogenesis in skeletal muscle and non-shivering thermogenesis in brown adipose tissue (BAT), the latter being mediated by uncoupled oxidation of free fatty acids (FFAs). We hypothesized that an acute temperature rise to 40 degrees C increases adrenalin-induced lipolysis in white adipocytes, thereby potentially providing FFAs as an energy substrate to sustain fever-induced thermogenesis in skeletal muscle and BAT. In 3T3-L1 and primary murine white adipocytes, isoproterenol-induced extracellular FFA accumulation was significantly increased at 40 degrees C compared to 37 degrees C. In contrast, isoproterenol-induced increase in extracellular glycerol concentrations and the protein levels of phosphorylated hormone sensitive lipase were comparable at both temperatures, suggesting a similar degree of lipolysis. Moreover, incubation at 40 degrees C did neither increase isoproterenol-induced oxygen consumption nor intracellular FFA concentrations, indicating that the elevated extracellular FFA accumulation was not due to reduced intracellular consumption. Conversely, isoproterenol blunted FFA uptake into adipocytes to a significantly higher extent at 40 degrees C compared to 37 degrees C. Hence, an acute temperature rise to 40 degrees C reduces FFA uptake into white adipocytes, thereby increasing extracellular FFA availability.
Keywords:
Fever
free fatty acid uptake
lipolysis
temperature
white adipose tissue
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