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An adventitial niche-based strategy with a hydroxysafflor yellow A-loaded hydrogel combined with ADSCs for diabetic limb ischemia
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DOI：10.1016/j.nantod.2026.103135.png)
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Abstract
En 中文
• A biomimetic alginate hydrogel scaffold (Gel-HP-ADSC) was developed to improve stem cell transplantation efficiency. • The alginate hydrogel, doped with nanofibers, mimics the multi-layered structure of the perivascular stroma. • Gel-HP-ADSC induces M2 macrophage polarization, exerting dual antioxidant and immunomodulatory effects. • Gel-HP-ADSC effectively promotes in vivo and in vitro angiogenesis activity, improving vascular remodeling.
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