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An age-related decrease in leptin contributes to CD8+ T cell aging in the tumor microenvironment
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DOI：10.1016/j.xcrm.2025.102310.png)
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Abstract
En 中文
• Intratumoral senescent CD8+ T cells increase with age • Adipocyte-derived leptin levels decrease with age • Age-related changes in leptin contribute to intratumoral CD8+ T cell aging • Leptin signaling prevents p38-dependent CD8+ T cell senescence
Keywords:
CD8+ T cells
aging
antitumor immunity
leptin
T cell senescence
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