An ageing biomarker signature predicts chronic disease cluster trajectories, physical function and mortality: validation in the TILDA and HRS cohorts

Belinda Hernández

doi:10.1093/ageing/afag135

An ageing biomarker signature predicts chronic disease cluster trajectories, physical function and mortality: validation in the TILDA and HRS cohorts

2026-05-20

0

OA

AI

B

Belinda Hernández *

E

Eric Klopack

F

Frank Moriarty

P

Padraic Fallon

N

Nollaig Bourke

E

Eileen Crimmins

R

Rose-Anne Kenny

C

Cathal Mc Crory

A

Aisling O'Halloran

DOI：10.1093/ageing/afag135

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Abstract

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Global population ageing is progressing at an unprecedented rate. Early identification of subpopulations at risk of chronic diseases could mitigate deteriorating health and increasing health service use, while revealing key biological cues and therapeutic targets. We hypothesised that a multisystem biomarker signature could identify future chronic disease trajectories, multimorbidity, functional decline and mortality.

Keywords:

biomarker signature

chronic disease trajectories

multimorbidity

physical function

mortality

An ageing biomarker signature predicts chronic disease cluster trajectories, physical function and mortality: validation in the TILDA and HRS cohorts

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