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An AIE-active NIR Ratiometric probe based on “ICT + ESIPT” mechanism for mitochondrial MAO imaging: Distinguishing cells and visualizing DILI

delete2026-04-30
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PRE
AI
T
Ting Cao
M
Mengjin Li
H
Hong Ma
Z
Zhefeng Fan *
DOI：10.1016/j.jphotochem.2026.117323delete
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Abstract

Abstract

En 中文
• A novel AIE-1 probe integrates “ICT + ESIPT+AIE” tri-modal for ratiometric NIR fluorescence imaging of MAO activity. • AIE-1 exhibits wide linear range (0–140 μg/mL), high sensitivity (LOD 0.23 μg/mL), and excellent selectivity. • AIE-1 semi-quantitatively distinguishes MAO activity in normal/cancer cells and evaluates cellular inhibitor efficacy. • Successful real-time visualization of upregulated MAO activity is achieved in a DILI model.
Keywords:
AIE-1
MAO activity
ratiometric NIR fluorescence imaging
mitochondrial imaging
DILI model

Journal

J
journal of photochemistry and photobiology a: chemistry
IF:
0
Papers:
301
Citations:
1

Organization

S
Shanxi Normal University
Scholars:
3.6K
Papers: 2.3K
Citations: 2.6K
T
Taiyuan Normal University
Scholars:
990
Papers: 712
Citations: 702
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