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An electrochemical biosensor integrating self-propelled nanocarriers with DNA cascade amplification strategy for ultrasensitive PPIA detection
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DOI：10.1016/j.bios.2026.119020.png)
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Abstract
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• Self-propelled PtNPs@COF accelerates PPIA binding via O2 generation. • DNAzyme release and CHA cascade amplify signal for ultrasensitive detection. • Detection limit of 0.330 pg/mL and wide linear range from 1 pg/mL to 10 μg/mL. • Reliably distinguishes lung adenocarcinoma patients from healthy controls.
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