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An emerging therapeutic strategy for major depressive disorder: targeting the protein-protein interactions
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DOI：10.1016/j.neuint.2026.106202.png)
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Abstract
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• Serotonin transporter is regulated by its interaction with the regulatory proteins • A novel therapeutic strategy for major depressive disorder is emerging • Regional regulation achieves a precise, fine-tuning modulation of SERT function • Targeting protein-protein interfaces produces fast-onset antidepressant effects
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