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An experimentally validated structure-based computational framework for humanisation of anti-orthopoxvirus antibodies
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DOI：10.1016/j.ebiom.2026.106405.png)
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Abstract
En 中文
The re-emergence of orthopoxviruses, most notably mpox virus (MPXV), poses a growing global public health threat. Well-characterised murine anti-orthopoxvirus antibodies are clinically limited by anti-mouse antibody responses, while traditional sequence-based humanisation often impairs antigen-binding activity.
Keywords:
Orthopoxvirus
Mpox virus
Antibody humanisation
Structure-guided design
Therapeutic antibodies
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