.png){kind=icon}
.png){kind=icon}
Return
Angiogenesis Factors as Emerging Circulating Biomarkers in Asthma
.png){kind=icon}
OA
AI
P
M
A
DOI：10.4168/aair.2025.17.1.22.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Angiogenesis is an important event in the development of allergic inflammation as well as in the pathophysiology of tissue remodeling in asthma. Increased angiogenesis is a welldocumented feature of airway remodeling in asthma. Angiogenesis refers to the formation of new blood vessels from pre-existing endothelium. Angiogenesis can be initiated by endogenous angiogenic factors released from mesenchymal cells or inflammatory cells. Under physiological conditions, angiogenesis is controlled by an equilibrium between proendogenous and anti-endogenous angiogenic factors released from the extracellular matrix to become bioavailable. The presence of increased size and number of bronchial blood vessels indicates that angiogenesis plays a crucial role in tissue growth and remodeling in asthma. However, the diagnostic significance of circulating angiogenic factors in asthma remains unclear. This review summarizes the role of angiogenesis in airway remodeling in asthma, and the potential diagnostic implications of circulating angiogenetic factors.
Keywords:
Angiogenesis
biomarkers
airway remodeling
asthma
Journal
A
IF:
4.3
Papers:
1.1K
Citations:
2.7K
Organization
Cited Papers