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Anti-inflammatory, antioxidant, and protective effects of methanolic extract of Paederia foetida and keracyanin in carrageenan-induced inflammation in rats: Integrated in silico, in vitro and in vivo mechanistic evidence targeting MAPK and NF-κB pathways
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DOI:10.1016/j.jep.2026.122069.png)
Abstract
En 中文
• Paederia foetida extract and keracyanin show multi-target anti-inflammatory effects. • Docking, dynamics & PASS analyses predict anti-inflammatory & antioxidant activity. • ADMET profiling supports drug-likeness, safety and translational potential. • P. foetida extract and keracyanin inhibit LOX, COX-2 and nitric oxide in vitro. • Treatments suppress inflammation by MAPK/NF-κB signaling & oxidative stress in rats.
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