.png){kind=icon}
.png){kind=icon}
Return
Anti-inflammatory ent-kaurane diterpenoids from the whole plants of Sphagneticola trilobata (L.) Pruski
.png){kind=icon}
PRE
AI
Y
X
J
J
X
Y
X
DOI：10.1016/j.phytochem.2026.114884.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Phytochemical investigation of the whole plants of Sphagneticola trilobata (L.) Pruski led to the isolation of thirteen ent-kaurane diterpenoids, including five previously undescribed compounds. Their structures were elucidated through comprehensive spectroscopic data analysis, DP4+ NMR computational calculations, and calculated electronic circular dichroism. All isolated diterpenoids were evaluated for the observed anti-NO production activity in lipopolysaccharide-stimulated RAW 264.7 macrophages. Among them, 16 alpha,17-dihydroxy-ent-kaur-9(11)-en-19-oic acid (6-O-caffeoyl-beta-D-glucopyranosyl) ester (4) and 12-oxo-16 alpha,17-dihydroxyent-kauran-19-oic acid (5) exhibited significant inhibition on nitric oxide production with IC50 values of 41.5 and 29.1 mu M, respectively. Further studies revealed that compounds 4 and 5 exerted anti-inflammatory effects by blocking the nuclear translocation of NF-kappa B, leading to the downregulation of key inflammatory mediators such as inducible nitric oxide synthase, cyclooxygenase-2, interleukin-1 beta, and interleukin-6. These findings underscore the potential of these ent-kaurane diterpenoids from S. trilobata as promising lead compounds for the development of anti-inflammatory agents.
Keywords:
Asteraceae
ent -kaurane diterpenoid
Anti-inflammation
Journal
IF:
3.4
Papers:
1.3W
Citations:
3.2W
Organization
Cited Papers