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Anti-influenza virus activities of triterpenes from the antler-shaped fruiting bodies of Ganoderma lucidum
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DOI：10.1016/j.phytochem.2026.114877.png)
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Abstract
En 中文
Ganoderma, a famous fungus, has traditionally been used in China for thousands of years. Fourteen previously undescribed triterpenes were isolated from the antler-shaped fruiting bodies of Ganoderma lucidum. Seven of these triterpenes showed inhibitory activity against influenza A virus (IAV) neuraminidase, with IC50 from 5.64 to 18.36 mu M. One triterpene exhibited anti-IAV activity in Madin-Darby canine kidney (MDCK) cells. Four triterpenes significantly reduced IAV-induced production of inflammatory cytokines IL-1 beta or IL-6 in A549 cells. Our findings suggest that Ganoderma triterpenes provide new opportunities for the treatment of respiratory viral diseases.
Keywords:
Ganoderma lucidum (Leyss. ex Fr.) karst
Ganodermataceae
Triterpenes
Anti-influenza A virus neuraminidase
Anti-influenza A virus
Anti-inflammatory cytokines
Journal
IF:
3.4
Papers:
1.3W
Citations:
3.2W
Organization
Cited Papers