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Antibacterial photocurable resin loaded with cetylpyridinium chloride for vat photopolymerization 3D printing in dental applications
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DOI：10.36922/IJB025470484.png)
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Abstract
En 中文
Bacterial adhesion and biofilm formation are critical issues for 3D-printed dental resin. This study aims to develop a novel cetylpyridinium chloride (CPC)-based antibacterial photocurable resin for vat photopolymerization (VPP) 3D printing and evaluate its printability, mechanical properties, antibacterial activities, and CPC-release behavior for potential use in dental prostheses and orthodontic devices. Photocurable resins containing 0-3 wt.% CPC were formulated from methacrylate and acrylate monomers. Printability of the photocurable resins was assessed by measuring viscosity, cure depth, over-curing, and the degree of conversion. The photocurable resins were printed using a VPP 3D printer, and the resulting specimens were evaluated for mechanical properties using three-point bending and Vickers hardness tests. Antibacterial activity against Streptococcus mutans was examined by bacterial viability and plaque-formation assays. CPC-release behavior was analyzed by UV-visible spectroscopy. CPC incorporation up to 3% slightly increased resin viscosity, cure depth, and over-curing while maintaining adequate printability. The degree of conversion was not significantly affected by CPC content. The 1% CPC-loaded printed resin exhibited mechanical properties comparable to the CPC-free control, whereas 3% CPC markedly reduced them. The 1% CPC-loaded resin showed strong antibacterial activity, achieving an antibacterial activity value of 5.6 (>99.99% bacterial reduction), and demonstrated sustained plaque inhibition. Sustained CPC release from the printed resins was confirmed throughout the 14-day evaluation period. These results demonstrate that 1% CPC-loading provides an optimal balance among printability, mechanical properties, and antibacterial performance. The developed material shows potential for application in 3D-printed dental polymer-based prostheses and orthodontic devices.
Keywords:
3D printing
Additive manufacturing
Antibacterials
Biomaterials
Cetylpyridinium chloride
Dental materials
Dental resin
Journal
I
IF:
6
Papers:
666
Citations:
2.8K